Abstract
Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Adenine Nucleotide Translocator 1 / metabolism
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Apoptosis / physiology*
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Humans
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Membrane Transport Proteins / metabolism
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Mitochondria / metabolism*
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Mitochondrial Membrane Transport Proteins / chemistry
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Mitochondrial Membrane Transport Proteins / genetics
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Mitochondrial Membrane Transport Proteins / metabolism*
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Mitochondrial Permeability Transition Pore
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Mitochondrial Proteins / metabolism
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Permeability
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Voltage-Dependent Anion Channels / metabolism
Substances
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Adenine Nucleotide Translocator 1
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MTCH2 protein, human
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Membrane Transport Proteins
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Mitochondrial Membrane Transport Proteins
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Mitochondrial Permeability Transition Pore
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Mitochondrial Proteins
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Proto-Oncogene Proteins c-bcl-2
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Voltage-Dependent Anion Channels