Abstract
The screening of 17 SAg genes of S. aureus isolated from the sputum of cystic fibrosis (CF) patients revealed that among 47 genetically different strains, 39 (83 %) carried SAg genes. Superantigens forming enterotoxin gene cluster were detected in 20 strains. The 2nd most common superantigen type was selk detected in 13 strains. In 9 strains, selk occurred together with the sea gene. Out of 74 strains recovered from nasal carriers, 56 (75 %) were found to carry SAg genes, 38 carried egc genes, while selk was detected in 5 strains. The predominant SAg types in both investigated S. aureus populations were egc and selk/sea, but selk gene frequency was significantly higher in the CF-derived strains.
MeSH terms
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Adolescent
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Antigens, Bacterial / analysis*
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Antigens, Bacterial / genetics
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Bacterial Proteins / genetics
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Carrier State / microbiology
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Child
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Child, Preschool
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Cystic Fibrosis / complications
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Cystic Fibrosis / microbiology*
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DNA, Bacterial / genetics
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Enterotoxins / genetics
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Genotype
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Humans
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Infant
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Infant, Newborn
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Nasal Cavity / microbiology
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Patients
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Sputum / microbiology
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / classification
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Staphylococcus aureus / genetics*
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Staphylococcus aureus / immunology*
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Staphylococcus aureus / isolation & purification
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Superantigens / analysis*
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Superantigens / genetics
Substances
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Antigens, Bacterial
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Bacterial Proteins
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DNA, Bacterial
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Enterotoxins
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Superantigens