Abstract
To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, Bacterial / immunology
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Biological Assay*
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Female
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Humans
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Interferon-gamma / immunology*
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Male
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Middle Aged
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Mycobacterium tuberculosis / immunology*
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Mycobacterium tuberculosis / physiology
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Sensitivity and Specificity
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Time Factors
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Tuberculosis / diagnosis*
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Virus Latency*
Substances
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Antigens, Bacterial
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Interferon-gamma