Abstract
Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.
MeSH terms
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Animals
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Chemistry, Pharmaceutical / methods
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Coccidiosis / drug therapy*
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Coccidiostats / chemistry
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Coccidiostats / pharmacology*
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Cyclic GMP-Dependent Protein Kinases / metabolism
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Drug Design
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Eimeria tenella
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Imidazoles / chemistry*
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Models, Chemical
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Structure-Activity Relationship
Substances
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Coccidiostats
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Imidazoles
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Protein Kinase Inhibitors
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Pyridines
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Cyclic GMP-Dependent Protein Kinases