Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent

M Hanekom; G D van der Spuy; N C Gey van Pittius; C R E McEvoy; S L Ndabambi; T C Victor; E G Hoal; P D van Helden; R M Warren

doi:10.1128/JCM.02354-06

Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent

J Clin Microbiol. 2007 Jul;45(7):2263-6. doi: 10.1128/JCM.02354-06. Epub 2007 May 2.

Authors

M Hanekom¹, G D van der Spuy, N C Gey van Pittius, C R E McEvoy, S L Ndabambi, T C Victor, E G Hoal, P D van Helden, R M Warren

Affiliation

¹ DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa.

Abstract

This study describes a comparative analysis of the Beijing mycobacterial interspersed repetitive unit types of Mycobacterium tuberculosis isolates from Cape Town, South Africa, and East Asia. The results show a significant association between the frequency of occurrence of strains from defined Beijing sublineages and the human population from whom they were cultured (P < 0.0001).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asia, Eastern / epidemiology
China
Genotype
Humans
Mycobacterium tuberculosis / classification
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / isolation & purification*
Polymorphism, Genetic
Population Dynamics
South Africa / epidemiology
Tuberculosis, Pulmonary / epidemiology
Tuberculosis, Pulmonary / microbiology*
Tuberculosis, Pulmonary / transmission*