Human frataxin: iron and ferrochelatase binding surface

Chem Commun (Camb). 2007 May 14:(18):1798-800. doi: 10.1039/b703195e. Epub 2007 Mar 28.

Abstract

The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein's ability to serve as the iron chaperone during heme biosynthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Crystallography, X-Ray
  • Ferrochelatase / metabolism*
  • Frataxin
  • Heme / biosynthesis
  • Humans
  • Iron / metabolism*
  • Iron-Binding Proteins / metabolism*
  • Magnetic Resonance Spectroscopy
  • Molecular Chaperones / metabolism
  • Surface Properties

Substances

  • Iron-Binding Proteins
  • Molecular Chaperones
  • Heme
  • Iron
  • Ferrochelatase