Abstract
The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein's ability to serve as the iron chaperone during heme biosynthesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Crystallography, X-Ray
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Ferrochelatase / metabolism*
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Frataxin
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Heme / biosynthesis
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Humans
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Iron / metabolism*
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Iron-Binding Proteins / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Chaperones / metabolism
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Surface Properties
Substances
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Iron-Binding Proteins
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Molecular Chaperones
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Heme
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Iron
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Ferrochelatase