Ectopic ossification of the triceps muscle after application of bone morphogenetic protein-7 to the distal humerus for recalcitrant nonunion: a case report

J Hand Surg Am. 2007 May-Jun;32(5):647-50. doi: 10.1016/j.jhsa.2007.03.001.

Abstract

We report a case of triceps muscle ectopic ossification and resultant elbow stiffness after application of recombinant human bone morphogenetic protein to a distal humerus nonunion site. We recommend caution when using this product in the upper extremity in regions where there is close approximation of soft tissue to bone and where loss of motion would be problematic.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Morphogenetic Proteins / administration & dosage
  • Bone Morphogenetic Proteins / adverse effects*
  • Fracture Fixation, Internal
  • Fractures, Ununited / surgery*
  • Humans
  • Humeral Fractures / surgery*
  • Ilium / transplantation
  • Male
  • Muscle, Skeletal / diagnostic imaging*
  • Ossification, Heterotopic / diagnostic imaging
  • Ossification, Heterotopic / etiology*
  • Radiography
  • Reoperation
  • Smoking / adverse effects

Substances

  • Bone Morphogenetic Proteins
  • osteogenic protein 1 putty, recombinant human