Autosomal dominant retinitis pigmentosa in Norway: a 20-year clinical follow-up study with molecular genetic analysis. Two novel rhodopsin mutations: 1003delG and I179F

Acta Ophthalmol Scand. 2007 May;85(3):287-97. doi: 10.1111/j.1600-0420.2006.00820.x.

Abstract

Purpose: To examine the clinical picture and molecular genetics of 12 Norwegian families with autosomal dominant retinitis pigmentosa (adRP) in order to achieve a genotype-phenotype correlation.

Methods: In addition to a clinical ophthalmological examination, fundus photography, dark adaptometry and electroretinography were performed. Four genes were analysed: rhodopsin (RHO); retinitis pigmentosa 1 (RP1); retinal degeneration slow/peripherin (RDS/peripherin), and inosine monophosphate dehydrogenase 1 (IMPDH1). Seven of the families had been examined about 20 years previously. A total of 63 patients or first-degree relatives (aged 18-79 years) were examined.

Results: Mutations were found only in the RHO gene. Seven families were given a diagnosis of classical RP. Two of them had novel mutation 1003delG, and one family had the mutation V345M. Four families had pericentral retinal dystrophy (PRD), two families with the mutation A164V and one with novel mutation I179F. One family was given a diagnosis of central and pericentral retinal dystrophy (CPRD), a special type of cone/rod dystrophy, and no mutation was found.

Conclusions: Six of 12 families had an RHO mutation. The mutation V345M and the novel mutation 1003delG both caused classical RP, the former indicating the most unfavourable prognosis. Two of the families with PRD had the A164V mutation with a favourable prognosis, whereas the novel mutation I179F caused PRD with extremely variable expressivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • DNA Mutational Analysis
  • Dark Adaptation
  • Electroretinography
  • Eye Proteins / genetics
  • Female
  • Follow-Up Studies
  • Frameshift Mutation*
  • Genes, Dominant
  • Humans
  • IMP Dehydrogenase / genetics
  • Intermediate Filament Proteins / genetics
  • Male
  • Membrane Glycoproteins / genetics
  • Microtubule-Associated Proteins
  • Middle Aged
  • Mutation, Missense*
  • Nerve Tissue Proteins / genetics
  • Norway / epidemiology
  • Pedigree
  • Peripherins
  • Phenotype
  • Photography
  • Polymerase Chain Reaction
  • Retinitis Pigmentosa / diagnosis
  • Retinitis Pigmentosa / epidemiology
  • Retinitis Pigmentosa / genetics*
  • Rhodopsin / genetics*
  • Visual Fields

Substances

  • Eye Proteins
  • Intermediate Filament Proteins
  • Membrane Glycoproteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • PRPH protein, human
  • PRPH2 protein, human
  • Peripherins
  • RP1 protein, human
  • Rhodopsin
  • IMP Dehydrogenase
  • IMPDH1 protein, human