High loading dose AmBisome is efficacious and well tolerated in the management of invasive fungal infection in hematology patients

Haematologica. 2007 Apr;92(4):572-3. doi: 10.3324/haematol.10531.

Abstract

Despite improved supportive care, and the introduction of less toxic lipid-formulations of amphotericin B deoxycholate and other new antifungal agents the mortality from invasive fungal infection (IFI) in hematology patients remains high. New management strategies are therefore required to improve outcome.

Publication types

  • Clinical Trial
  • Letter
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amphotericin B / administration & dosage*
  • Amphotericin B / adverse effects
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / adverse effects
  • Antifungal Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Female
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / drug therapy
  • Hematologic Neoplasms / surgery
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunocompromised Host
  • Kidney Diseases / chemically induced
  • Liposomes / administration & dosage
  • Male
  • Middle Aged
  • Mycoses / drug therapy*
  • Mycoses / etiology
  • Mycoses / mortality
  • Postoperative Complications / drug therapy
  • Postoperative Complications / etiology
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Liposomes
  • liposomal amphotericin B
  • Amphotericin B