Abstract
Fragile X syndrome is, after Down's syndrome, the most common form of mental retardation. Women are potential carriers and can have the defective gene on one of their two X chromosomes without developing the complete syndrome. In this paper we examine which psychiatric disturbances may appear or develop in women because they are carriers of the fragile X mutation. Carriers have been found to have a higher frequency of anxiety disorders, affective disorders and schizotypal features.
MeSH terms
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Affective Disorders, Psychotic / epidemiology*
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Affective Disorders, Psychotic / genetics
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Anxiety Disorders / epidemiology*
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Anxiety Disorders / genetics
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Female
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Fragile X Mental Retardation Protein / genetics*
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Fragile X Syndrome / complications
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Fragile X Syndrome / genetics*
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Fragile X Syndrome / psychology
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Heterozygote*
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Humans
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Male
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Mutation
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Schizotypal Personality Disorder / epidemiology*
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Schizotypal Personality Disorder / genetics
Substances
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Fragile X Mental Retardation Protein