Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage

J Am Chem Soc. 2007 Jun 6;129(22):6976-7. doi: 10.1021/ja0705994. Epub 2007 May 15.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Humans
  • Hydrolysis
  • Immunoglobulin Fragments / chemistry
  • Immunoglobulin Fragments / metabolism
  • Immunoglobulin G / chemistry*
  • Immunoglobulin G / metabolism*
  • Peptides / chemistry*
  • Peptides / metabolism*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Immunoglobulin Fragments
  • Immunoglobulin G
  • Peptides