Abstract
Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alanine Transaminase / blood
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Anti-Retroviral Agents / therapeutic use
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Antiretroviral Therapy, Highly Active
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CD4 Lymphocyte Count
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Case-Control Studies
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / immunology
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HIV* / genetics
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HIV* / isolation & purification
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Hepacivirus / genetics
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Hepacivirus / isolation & purification
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Hepacivirus / physiology*
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Hepatitis B Surface Antigens / blood
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Hepatitis B virus / physiology*
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Hepatitis B, Chronic / blood
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Hepatitis B, Chronic / complications*
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Hepatitis C Antibodies / blood
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Hepatitis C, Chronic / blood
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / virology*
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Humans
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Male
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RNA, Viral / blood
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Retrospective Studies
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Viral Interference*
Substances
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Anti-Retroviral Agents
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Hepatitis B Surface Antigens
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Hepatitis C Antibodies
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RNA, Viral
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Alanine Transaminase