Abstract
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / antagonists & inhibitors*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Cattle
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Dose-Response Relationship, Drug
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Molecular Structure
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Salmonella typhimurium / classification
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Salmonella typhimurium / metabolism*
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Salmonella typhimurium / pathogenicity*
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Serotyping
Substances
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Anti-Bacterial Agents
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Bacterial Proteins