Enteropathy-type T-cell lymphoma

Am J Clin Pathol. 2007 May;127(5):701-6. doi: 10.1309/nw2bk1dxb0eqg55h.

Abstract

Session 7 of the Society for Hematopathology/European Association for Haematopathology Workshop was devoted to case presentations and discussion of enteropathy-type T-cell lymphoma (ETL) and other T-cell lymphomas involving the gastrointestinal tract. ETL is a rare type of T-cell lymphoma, often associated with a history of celiac disease, that usually arises in the jejunum but can involve other gastrointestinal tract sites (eg, stomach and colon). As the cases submitted illustrate, there are 2 histologic groups of ETL that correlate with clinical and immunophenotypic features. Pleomorphic-anaplastic ETL is usually associated with a history of celiac disease and histologic evidence of enteropathy and is most often CD56-. Monomorphic ETL often occurs without a history of celiac disease, has variable histologic evidence of enteropathy, and is usually CD56+. Comparative genomic hybridization has shown recurrent chromosomal gains and losses that are characteristic of ETL and uncommon in other T-cell lymphomas, providing useful ancillary data for the diagnosis of ETL.

Publication types

  • Review

MeSH terms

  • CD56 Antigen / analysis
  • Celiac Disease / pathology
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 9
  • Humans
  • In Situ Hybridization, Fluorescence
  • Intestinal Neoplasms / classification
  • Intestinal Neoplasms / genetics
  • Intestinal Neoplasms / pathology*
  • Lymphoma, T-Cell / classification
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / pathology*

Substances

  • CD56 Antigen