Immunological synapses: breaking up may be good to do

Matthew F Krummel

doi:10.1016/j.cell.2007.05.008

Immunological synapses: breaking up may be good to do

Cell. 2007 May 18;129(4):653-5. doi: 10.1016/j.cell.2007.05.008.

Author

Matthew F Krummel¹

Affiliation

¹ The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0511, USA. [email protected]

PMID: 17512399
DOI: 10.1016/j.cell.2007.05.008

Abstract

Activated T cells form stable immunological synapses with antigen-presenting cells whereas naïve T cells initially engage in more transient interactions. Sims et al. (2007) demonstrate that these transient interactions are due to the kinase PKCtheta, which serves to destabilize the synapse thereby permitting T cells to migrate elsewhere. They also show that re-establishment of a synapse involves the actin regulator WASp.

Publication types

Review
Comment

MeSH terms

Animals
Antigen Presentation / immunology
Cell Communication / immunology*
Cell Movement / immunology
Humans
Isoenzymes / immunology
Lymphocyte Activation / immunology*
Protein Kinase C / immunology
Protein Kinase C-theta
Signal Transduction / immunology
T-Lymphocytes / immunology*
Wiskott-Aldrich Syndrome Protein Family / metabolism

Substances

Isoenzymes
Wiskott-Aldrich Syndrome Protein Family
PRKCQ protein, human
Protein Kinase C
Protein Kinase C-theta