Abstract
Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Retroviral Agents / pharmacology*
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DNA, Viral / blood*
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Drug Resistance, Viral / genetics*
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HIV / drug effects*
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HIV / genetics
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HIV Infections / drug therapy*
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Humans
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Leukocytes, Mononuclear / physiology
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Leukocytes, Mononuclear / virology*
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Molecular Sequence Data
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Mutation / drug effects
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Mutation / genetics
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Sensitivity and Specificity
Substances
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Anti-Retroviral Agents
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DNA, Viral