Abstract
Setting:
Tertiary hospitals in KwaZulu Natal, South Africa.
Objective:
To study the impact of multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus-1 (HIV-1) co-infection during pregnancy on maternal and perinatal outcome.
Design:
Prospective study performed between 1996 and 2001. Symptomatic pregnant women were investigated for TB. Those with confirmed MDR-TB were reported on.
Results:
Three of five pregnant women with MDR-TB were HIV-1 co-infected. One woman decided to terminate the pregnancy and one experienced pre-term labour. Two neonates had features of growth restriction.
Conclusion:
Management of pregnant women with MDR-TB in an HIV-endemic area is possible in developing countries.
MeSH terms
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Abortion, Induced
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Abortion, Spontaneous
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Adolescent
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Adult
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Antitubercular Agents / adverse effects
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Female
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Fetal Growth Retardation / etiology
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HIV Infections / complications*
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HIV Infections / diagnosis
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HIV Infections / transmission
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HIV Infections / virology
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HIV-1*
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Humans
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Infectious Disease Transmission, Vertical
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Live Birth
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Mycobacterium tuberculosis / isolation & purification
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Pregnancy
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Pregnancy Complications, Infectious / diagnosis*
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Pregnancy Complications, Infectious / drug therapy
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Pregnancy Complications, Infectious / microbiology
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Pregnancy Complications, Infectious / virology
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Prospective Studies
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South Africa
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Sputum / microbiology
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Tuberculosis, Multidrug-Resistant / complications*
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Tuberculosis, Multidrug-Resistant / diagnosis
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Tuberculosis, Multidrug-Resistant / drug therapy
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Tuberculosis, Multidrug-Resistant / microbiology
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Tuberculosis, Multidrug-Resistant / transmission