Contamination of peripheral hematopoeitic stem cell products with a Mycobacterium mucogenicum-related pathogen

Infect Control Hosp Epidemiol. 2007 Jun;28(6):755-7. doi: 10.1086/516666. Epub 2007 May 15.

Abstract

A gram-positive rod with a restriction pattern closely related to the published nucleotide sequence of Mycobacterium mucogenicum was isolated from 6 of 45 units of peripheral blood stem cell products. The source of the contamination was traced to ice cubes used in processing the peripheral blood stem cell products. Substituting reusable ice trays for ice from an ice machine terminated the outbreak.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bone Marrow Transplantation
  • Disease Outbreaks / prevention & control
  • Equipment Contamination*
  • Hematopoietic Stem Cells / microbiology*
  • Humans
  • Ice / adverse effects*
  • Infection Control / methods
  • Mycobacterium / isolation & purification*
  • Mycobacterium Infections / drug therapy
  • Mycobacterium Infections / microbiology*
  • Polymerase Chain Reaction

Substances

  • Anti-Bacterial Agents
  • Ice