Abstract
Stalled replication forks produced by three different ways of depleting deoxynucleoside triphosphate showed different capacities to undergo "replication fork reversal." This reaction occurred at the stalled forks generated by hydroxyurea treatment, was impaired under thermal inactivation of ribonucleoside reductase, and did not take place under thymine starvation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA Breaks, Double-Stranded*
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DNA Replication
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DNA, Bacterial / genetics*
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DNA, Bacterial / metabolism
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Deoxyribonucleotides / metabolism*
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Escherichia coli / genetics*
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Escherichia coli / metabolism*
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Ribonucleoside Diphosphate Reductase / metabolism
Substances
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DNA, Bacterial
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Deoxyribonucleotides
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Ribonucleoside Diphosphate Reductase