Exploiting a list of protein sequences

Gene. 2007 Aug 15;398(1-2):35-41. doi: 10.1016/j.gene.2007.01.036. Epub 2007 Apr 27.

Abstract

We describe a software program to help exploit a database of aligned protein sequences. In addition to the classical lists of sequences, a graphical representation is used to get a better overview of the information. As natural parameters, the type of amino acid and sequence position are used. Various plots or 3D representations are then updated. Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry
  • Amino Acids / genetics
  • Animals
  • Computer Graphics
  • Databases, Protein
  • Hemoglobins / chemistry*
  • Hemoglobins / genetics
  • Humans
  • Models, Molecular*
  • Mutation
  • Protein Conformation
  • Protein Structure, Tertiary
  • Software*

Substances

  • Amino Acids
  • Hemoglobins