Abstract
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
MeSH terms
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Acetates / chemistry
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Acetates / pharmacology*
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Animals
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Biological Availability
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Eosinophils / drug effects
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Humans
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Rats
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Receptors, Immunologic / antagonists & inhibitors*
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Receptors, Prostaglandin / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Acetates
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Receptors, Immunologic
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Receptors, Prostaglandin
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prostaglandin D2 receptor
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phenoxyacetic acid