The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids
Arq Bras Cardiol. 2007 Mar;88(3):297-303.
doi: 10.1590/s0066-782x2007000300008.
[Article in
English,
Portuguese]
Affiliation
- 1 Instituto do Coração, Hospital das Clínicas, FM, USP, São Paulo, SP, Brazil.
Abstract
Objective:
The objective of this study was to evaluate the effect of polymorphism S447X on plasma lipids of patients with premature coronary artery disease (CAD).
Methods:
Plasma lipids and genotypes were determined in 2 groups: 313 patients with premature CAD (<55 years of age) and 150 controls without CAD.
Results:
Frequency of the S447X polymorphism was 18% in patients with CAD and 23% in the control group. The S447X polymorphism of lipoprotein lipase is related to a decrease in plasma triglyceride concentrations in male patients with CAD, but this correlation is not observed in female patients.
Conclusion:
The presence of the S447X lipoprotein lipase polymorphism was not associated with the incidence of CAD.
MeSH terms
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Adult
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Brazil / epidemiology
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Cholesterol / blood
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Coronary Artery Disease / blood
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Coronary Artery Disease / epidemiology
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Coronary Artery Disease / genetics*
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Epidemiologic Methods
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Female
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Genotype
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Humans
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Lipids / blood*
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Lipoprotein Lipase / genetics*
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Male
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Middle Aged
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Polymorphism, Genetic / genetics*
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Sex Factors
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Triglycerides / blood
Substances
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Lipids
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Triglycerides
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Cholesterol
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Lipoprotein Lipase