Botulinum neurotoxin A: an unusual systemic effect

Katherine Howell; Paulo Selber; H Kerr Graham; Dinah Reddihough

doi:10.1111/j.1440-1754.2007.01122.x

Botulinum neurotoxin A: an unusual systemic effect

J Paediatr Child Health. 2007 Jun;43(6):499-501. doi: 10.1111/j.1440-1754.2007.01122.x.

Authors

Katherine Howell¹, Paulo Selber, H Kerr Graham, Dinah Reddihough

Affiliation

¹ Department of Child Development and Rehabilitation, Royal Children's Hospital, Parkville, Victoria, Australia.

PMID: 17535186
DOI: 10.1111/j.1440-1754.2007.01122.x

Abstract

Systemic effects from Botulinum neurotoxin A are uncommon but can have serious consequences. We report the case of a boy with severe cerebral palsy who developed deterioration in respiratory and oromotor function following repeated injections of Botulinum neurotoxin A. Caution is needed in using this treatment in children with severe cerebral palsy and pseudobulbar palsy.

Publication types

Case Reports

MeSH terms

Botulinum Toxins, Type A / adverse effects*
Botulinum Toxins, Type A / therapeutic use
Cerebral Palsy / complications*
Child
Deglutition Disorders / etiology
Humans
Male
Neuromuscular Agents / adverse effects*
Neuromuscular Agents / therapeutic use
Pseudobulbar Palsy / drug therapy*
Respiratory Sounds / etiology

Substances

Neuromuscular Agents
Botulinum Toxins, Type A