Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin

J Am Chem Soc. 2007 Jun 27;129(25):7728-9. doi: 10.1021/ja071886a. Epub 2007 Jun 1.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / biosynthesis*
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Carboxylic Acids / chemistry
  • Carboxylic Acids / metabolism*
  • Coenzyme A / metabolism*
  • Gene Expression Regulation, Bacterial
  • Molecular Structure
  • Multigene Family
  • Naphthalenes / chemistry
  • Naphthalenes / metabolism*
  • Streptomyces / enzymology
  • Zinostatin / biosynthesis*

Substances

  • Antibiotics, Antineoplastic
  • Bacterial Proteins
  • Carboxylic Acids
  • Naphthalenes
  • 1-naphthoic acid
  • Zinostatin
  • Coenzyme A