Turning back the clock on neurodegeneration

Kile P Mangan; Jonathan M Levenson

doi:10.1016/j.cell.2007.05.033

Turning back the clock on neurodegeneration

Cell. 2007 Jun 1;129(5):851-3. doi: 10.1016/j.cell.2007.05.033.

Authors

Kile P Mangan¹, Jonathan M Levenson

Affiliation

¹ Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719, USA.

PMID: 17540162
DOI: 10.1016/j.cell.2007.05.033

Abstract

Does neuronal loss associated with dementia necessarily impair the ability to learn new information and recall old memories? In a recent report in Nature, Fischer et al. (2007) show that the ability to learn and remember can be reestablished in a mouse model of dementia through either environmental enrichment or chronic treatment with an inhibitor of histone deacetylase.

MeSH terms

Animals
Dementia / drug therapy
Dementia / therapy*
Disease Models, Animal
Enzyme Inhibitors / therapeutic use
Histone Deacetylase Inhibitors
Learning
Memory
Mice
Nerve Degeneration / drug therapy
Nerve Degeneration / therapy*

Substances

Enzyme Inhibitors
Histone Deacetylase Inhibitors