Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Cell Transformation, Neoplastic / immunology
-
Cell Transformation, Neoplastic / pathology*
-
Disease Models, Animal
-
Macrophages / immunology
-
Macrophages / pathology*
-
Mammary Neoplasms, Experimental / blood supply*
-
Mammary Neoplasms, Experimental / immunology
-
Mammary Neoplasms, Experimental / pathology
-
Mice
-
Mice, Transgenic
-
Neovascularization, Pathologic / immunology
-
Neovascularization, Pathologic / pathology