Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r

Dehai Li; Fengping Wang; Shengxin Cai; Xiang Zeng; Xiang Xiao; Qianqun Gu; Weiming Zhu

doi:10.1038/ja.2007.40

Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r

J Antibiot (Tokyo). 2007 May;60(5):317-20. doi: 10.1038/ja.2007.40.

Authors

Dehai Li¹, Fengping Wang, Shengxin Cai, Xiang Zeng, Xiang Xiao, Qianqun Gu, Weiming Zhu

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.

PMID: 17551210
DOI: 10.1038/ja.2007.40

Abstract

Two new bisorbicillinoids, named oxosorbiquinol (1) and dihydrooxosorbiquinol (2), were isolated from a deep-sea fungus, Phialocephala sp., and their structures established using spectroscopic methods. The absolute configurations of 1 and 2 were determined by their biosynthesis route and analysis of the CD spectrum. Their cytotoxic effects on P388, A-549, HL60, BEL7402 and K562 cell lines were examined by the MTT method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology
Ascomycota / chemistry*
Cell Line, Tumor
Chemical Phenomena
Chemistry, Physical
Circular Dichroism
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrophotometry, Infrared
Tetrazolium Salts
Thiazoles

Substances

Antibiotics, Antineoplastic
Diterpenes
Tetrazolium Salts
Thiazoles
dihydrooxosorbiquinol
oxosorbiquinol
thiazolyl blue