16S rRNA methylase-producing, gram-negative pathogens, Japan

Kunikazu Yamane; Jun-ichi Wachino; Satowa Suzuki; Naohiro Shibata; Haru Kato; Keigo Shibayama; Kouji Kimura; Kumiko Kai; Satoshi Ishikawa; Yoshiyuki Ozawa; Toshifumi Konda; Yoshichika Arakawa

doi:10.3201/eid1304.060501

16S rRNA methylase-producing, gram-negative pathogens, Japan

Emerg Infect Dis. 2007 Apr;13(4):642-6. doi: 10.3201/eid1304.060501.

Authors

Kunikazu Yamane¹, Jun-ichi Wachino, Satowa Suzuki, Naohiro Shibata, Haru Kato, Keigo Shibayama, Kouji Kimura, Kumiko Kai, Satoshi Ishikawa, Yoshiyuki Ozawa, Toshifumi Konda, Yoshichika Arakawa

Affiliation

¹ National Institute of Infectious Diseases, Tokyo, Japan.

Abstract

To investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoglycosides / pharmacology
Anti-Bacterial Agents / pharmacology
Dibekacin / analogs & derivatives
Dibekacin / pharmacology
Drug Resistance, Bacterial*
Electrophoresis, Gel, Pulsed-Field
Female
Gram-Negative Bacteria / drug effects*
Gram-Negative Bacteria / enzymology*
Gram-Negative Bacteria / genetics
Gram-Negative Bacteria / isolation & purification
Gram-Negative Bacterial Infections / microbiology*
Humans
Japan
Methyltransferases / genetics*
Microbial Sensitivity Tests
RNA, Ribosomal, 16S / genetics

Substances

Aminoglycosides
Anti-Bacterial Agents
RNA, Ribosomal, 16S
Dibekacin
Methyltransferases
rRNA (adenosine-O-2'-)methyltransferase
arbekacin