Protein tumor antigens

Curr Opin Immunol. 1991 Oct;3(5):654-8. doi: 10.1016/0952-7915(91)90092-f.

Abstract

Immunogenic tumor antigens have been sought through a variety of paradigms for several past decades. Recent developments in antigen presentation have radically changed the prism through which we view these enigmatic antigens. This article discusses the small but growing treasure chest of these antigens--stress-induced proteins, the P1AB antigen of the P815 mastocytoma, the p53 tumor suppressor protein, the gp95/p97 antigen of human melanoma, mucins and others.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Neoplasm / analysis
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology*
  • Gene Expression Regulation, Neoplastic
  • Heat-Shock Proteins / immunology
  • Humans
  • Immunity, Cellular
  • Mast-Cell Sarcoma / immunology
  • Mice
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / immunology*
  • Neoplasm Transplantation
  • Neoplasms / immunology*
  • T-Lymphocytes / immunology
  • Transplantation, Heterologous
  • Tumor Suppressor Protein p53 / immunology

Substances

  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Heat-Shock Proteins
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53