Abstract
Collateral circulation influences cerebral infarction occurrence and size. Statins may improve ischemic stroke outcomes. We evaluated the relationship between prestroke statin use and pretreatment angiographic collateral grade among acute ischemic stroke patients presenting with occlusion of a major cerebral artery. After adjusting for covariates, the statin-treated group had significantly higher collateral scores than non-statin users, suggesting an association between statin use and better collateralization during acute stroke.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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Age Factors
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Aged
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Aged, 80 and over
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Brain Ischemia / drug therapy*
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Brain Ischemia / physiopathology
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Cerebral Arteries / drug effects*
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Cerebral Arteries / physiopathology
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Cerebrovascular Circulation / drug effects
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Cerebrovascular Circulation / physiology
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Collateral Circulation / drug effects*
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Female
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Hypertension / complications
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Hypertension / physiopathology
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Male
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Microcirculation / drug effects*
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Microcirculation / physiopathology
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Middle Aged
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Prospective Studies
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Recovery of Function / drug effects
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Recovery of Function / physiology
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Retrospective Studies
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Stroke / drug therapy*
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Stroke / physiopathology
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Treatment Outcome
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors