Marine biology. Florida red tide brews up drug lead for cystic fibrosis

Science. 2007 Jun 15;316(5831):1561-2. doi: 10.1126/science.316.5831.1561.

Abstract

Among the nasty compounds produced by the organism responsible for Florida’s red tides is one with some surprising properties

Publication types

  • News

MeSH terms

  • Amiloride / pharmacology
  • Animals
  • Bronchoconstriction / drug effects
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / metabolism
  • Dinoflagellida / chemistry*
  • Disease Models, Animal
  • Ethers / metabolism
  • Ethers / pharmacology*
  • Ethers / therapeutic use
  • Humans
  • Ion Transport
  • Lung / drug effects
  • Lung / metabolism
  • Marine Toxins / metabolism
  • Marine Toxins / toxicity
  • Mucociliary Clearance / drug effects
  • Oxocins / metabolism
  • Oxocins / toxicity
  • Polymers / metabolism
  • Polymers / pharmacology*
  • Polymers / therapeutic use
  • Sheep
  • Sodium / metabolism
  • Sodium Channels / metabolism
  • Trichechus

Substances

  • Ethers
  • Marine Toxins
  • Oxocins
  • Polymers
  • Sodium Channels
  • brevenal (polyether)
  • Amiloride
  • brevetoxin
  • Sodium