Pulmonary arterial hypertension in a patient with common variable immunodeficiency and unilateral bronchiectasis: Successful treatment with iloprost

Z Daniil; E Karetsi; E Zakynthinos; E Bakratsi; F Kalala; K I Gourgoulianis

doi:10.1016/j.ejim.2006.11.014

Pulmonary arterial hypertension in a patient with common variable immunodeficiency and unilateral bronchiectasis: Successful treatment with iloprost

Eur J Intern Med. 2007 Jul;18(4):333-5. doi: 10.1016/j.ejim.2006.11.014. Epub 2007 May 18.

Authors

Z Daniil¹, E Karetsi, E Zakynthinos, E Bakratsi, F Kalala, K I Gourgoulianis

Affiliation

¹ Department of Respiratory Medicine, Medical School, University of Thessaly, University Hospital of Larissa, 41110 Mezourlo, Larissa, Greece.

PMID: 17574112
DOI: 10.1016/j.ejim.2006.11.014

Abstract

The present study describes a case of severe pulmonary arterial hypertension (PAH) associated with unilateral lung destruction due to bronchiectasis in a patient with common variable immunodeficiency (CVID). Initially, the patient's treatment included antibiotics, oral anticoagulants, diuretics, and immunoglobulin replacement therapy. However, the patient's condition improved significantly only after inhaled iloprost was administered. Three months later, his PAH was almost reversed. The hemodynamic response of our patient suggests that inhaled iloprost may have a role in the treatment of sustained PAH related to unilateral lung destruction.