Abstract
Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Brazil / epidemiology
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Cross Infection / microbiology
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Drug Resistance, Bacterial / genetics*
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Electrophoresis, Polyacrylamide Gel
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Humans
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Imipenem / pharmacology*
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Methyltransferases / biosynthesis
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Methyltransferases / genetics*
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Microbial Sensitivity Tests
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Pseudomonas Infections / epidemiology
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Pseudomonas Infections / microbiology*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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beta-Lactamases / biosynthesis
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Imipenem
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Methyltransferases
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16S rRNA (adenine(1518)-N(6)-adenine(1519)-N(6))-dimethyltransferase
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beta-Lactamases