Abstract
The possible generalization to diazepam of the dampened response to ethanol in sons of alcoholic fathers was evaluated in 62 sons of alcoholics (family history positive [FHP] subjects) and 62 family history negative (FHN) controls (124 men). Following challenges with placebo, .12 and .2 mg/kg of diazepam in three separate sessions, evaluation of subjective feelings and increases in body sway revealed no decreased reaction for FHPs.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alcohol Drinking / genetics*
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Alcohol Drinking / psychology*
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Alcoholism / genetics*
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Alcoholism / psychology*
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Child of Impaired Parents / psychology*
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Diazepam / pharmacology*
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Dose-Response Relationship, Drug
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Double-Blind Method
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Ethanol / pharmacology
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Humans
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Male
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Postural Balance / drug effects*