Between 1986 and 2005, 54 patients were hospitalized for rabies in the infectious diseases clinic, with an average of 3 cases a year. The patients came from almost all regions of Senegal, Dakar (11 cases), Thiès (9 cases), and Fatick (9 cases). They were native of rural and suburban zones. The median age was 19 years (range 5-72). Children and teenagers between 5 and 15 years of age were the most concerned (53.7%). Stray dogs were the main vector (75% of cases) but a case of bite by a puppy and a case of bite by a jackal were noted. Bites were mostly located in limb extremities (98%). Only 12 patients consulted a health institution after the bite and among these cases, 4 were referred to the Dakar Pasteur Institute but consulted late. Incubation was 45 days on average (range 25 to 90 days). All our patients presented a furious form of rabies. The average duration of hospital stay was 6 days (range 1-15 days). The local investigation proved an under reporting of cases in a proportion of 1 case reported for 4 non-reported cases.