Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

T Z Aziz; D Peggs; M A Sambrook; A R Crossman

doi:10.1002/mds.870060404

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

Mov Disord. 1991;6(4):288-92. doi: 10.1002/mds.870060404.

Authors

T Z Aziz¹, D Peggs, M A Sambrook, A R Crossman

Affiliation

¹ Department of Cell and Structural Biology, University of Manchester Medical School, U.K.

PMID: 1758446
DOI: 10.1002/mds.870060404

Abstract

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

MeSH terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain Mapping
Dominance, Cerebral / drug effects
Dominance, Cerebral / physiology
Macaca fascicularis
Neurologic Examination
Parkinson Disease, Secondary / chemically induced
Parkinson Disease, Secondary / physiopathology
Parkinson Disease, Secondary / surgery*
Radiosurgery*
Thalamic Nuclei / physiopathology
Thalamic Nuclei / surgery*

Substances

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine