Abstract
A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / pharmacology
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HIV-1 / drug effects
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Lignans / chemistry*
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Lignans / pharmacology
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Molecular Structure
Substances
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Antineoplastic Agents
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Antiviral Agents
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Biphenyl Compounds
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Lignans
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magnolol
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honokiol