Asymmetric cyclopropanation of styrenes catalyzed by metal complexes of D2-symmetrical chiral porphyrin: superiority of cobalt over iron

J Org Chem. 2007 Jul 20;72(15):5931-4. doi: 10.1021/jo070997p. Epub 2007 Jun 23.

Abstract

The cobalt(II) complex of D2-symmetric chiral porphyrin [Co(1)] is an effective catalyst for highly diastereoselective and enantioselective cyclopropanation of a broad range of styrene derivatives under mild conditions. Dimerization of diazo compounds, a common side reaction in metal-mediated carbene transfer processes, is minimized in a cobalt porphyrin-based system, obviating the need to employ excess substrates and slow addition of diazo compounds. The high catalytic activity and selectivity of [Co(1)] evidently resulted from the appropriate combination of the cobalt ion and the chiral porphyrin 1 as the use of iron(III) complex of the same ligand [Fe(1)Cl] afforded the desired cyclopropane products in low yields and poor enantioselectivity.