Optimized pH-responsive cyanine fluorochromes for detection of acidic environments

Chem Commun (Camb). 2007 Jul 14:(26):2747-9. doi: 10.1039/b703764c. Epub 2007 Apr 20.

Abstract

Modulation of pH-responsive cyanine dye pK(a) values via heteroatom substitution allows for design of fluorescent reporters that are tuned for potential imaging of biologically relevant acidic environments.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acids / chemistry*
  • Carbocyanines / chemistry*
  • Fluorescent Dyes / chemistry*

Substances

  • Acids
  • BEBO cyanine dye
  • Carbocyanines
  • Fluorescent Dyes