Viral dynamics in transplant patients: implications for disease

Lancet Infect Dis. 2007 Jul;7(7):460-72. doi: 10.1016/S1473-3099(07)70159-7.

Abstract

Viral infections cause substantial morbidity and mortality in transplant patients. Quantifying viral loads is widely appreciated as a direct means to diagnose and monitor the course of viral infections. Recent studies indicate that the kinetics of viral load changes rather than single viral load measurements better correlate with organ involvement. In this Review, we will summarise the current knowledge regarding the kinetics of viruses relevant to transplantation including cytomegalovirus, Epstein-Barr virus, the herpes viruses 6 and 7, hepatitis C virus, GB virus C, adenovirus, and the emerging human polyomavirus type BK. We discuss the implications of viral kinetics for organ pathology as well as for the evaluation of antiviral interventions in transplant patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Transplantation*
  • Viral Load*
  • Virus Diseases / diagnosis*
  • Virus Diseases / drug therapy*
  • Virus Diseases / virology
  • Viruses / growth & development*