Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Ryotaro Morinaga; Isamu Okamoto; Kazuyuki Furuta; Yukiko Kawano; Masaru Sekijima; Kensaku Dote; Takao Satou; Kazuto Nishio; Masahiro Fukuoka; Kazuhiko Nakagawa

doi:10.1016/j.lungcan.2007.05.014

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Lung Cancer. 2007 Dec;58(3):411-3. doi: 10.1016/j.lungcan.2007.05.014. Epub 2007 Jun 29.

Authors

Ryotaro Morinaga¹, Isamu Okamoto, Kazuyuki Furuta, Yukiko Kawano, Masaru Sekijima, Kensaku Dote, Takao Satou, Kazuto Nishio, Masahiro Fukuoka, Kazuhiko Nakagawa

Affiliation

¹ Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.

PMID: 17601631
DOI: 10.1016/j.lungcan.2007.05.014

Abstract

We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC.

Publication types

Case Reports

MeSH terms

Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology*
Carcinoma, Small Cell / genetics*
Carcinoma, Small Cell / pathology*
ErbB Receptors / genetics*
Female
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology*
Middle Aged
Mutation / genetics
Tomography Scanners, X-Ray Computed

Substances

ErbB Receptors