Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor

Sadahisa Okamoto; Teruyuki Hirano; Yukitoshi Takahashi; Taro Yamashita; Eiichiro Uyama; Makoto Uchino

doi:10.2169/internalmedicine.46.6466

Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor

Intern Med. 2007;46(13):1019-22. doi: 10.2169/internalmedicine.46.6466. Epub 2007 Jul 2.

Authors

Sadahisa Okamoto¹, Teruyuki Hirano, Yukitoshi Takahashi, Taro Yamashita, Eiichiro Uyama, Makoto Uchino

Affiliation

¹ Department of Neurology, Graduate School of Medical Sciences, Kumamoto University. [email protected]

PMID: 17603244
DOI: 10.2169/internalmedicine.46.6466

Abstract

We report a rare case of paraneoplastic limbic encephalitis with autoantibodies to glutamate receptor (GluR) in the cerebrospinal fluid (CSF). The 35-year-old woman with consciousness disturbance was diagnosed initially as non-herpetic encephalitis. Her signs and symptoms improved with acyclovir and steroid pulse therapy. However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested.

Publication types

Case Reports

MeSH terms

Adult
Autoantibodies / analysis
Autoantibodies / immunology*
Biopsy, Needle
Female
Follow-Up Studies
Humans
Immunohistochemistry
Japan
Limbic Encephalitis / etiology*
Limbic Encephalitis / immunology
Ovarian Neoplasms / complications*
Ovarian Neoplasms / pathology
Ovarian Neoplasms / surgery
Ovariectomy / methods
Rare Diseases
Receptors, Glutamate / immunology*
Risk Assessment
Teratoma / complications*
Teratoma / pathology
Teratoma / surgery
Treatment Outcome

Substances

Autoantibodies
Receptors, Glutamate