False positive galactomannan results in adult hematological patients treated with piperacillin-tazobactam

Rev Iberoam Micol. 2007 Jun;24(2):106-12. doi: 10.1016/s1130-1406(07)70023-2.

Abstract

In this prospective study including 78 adult patients with haematological malignancy (90 episodes) we performed galactomannan (GM) (Platelia Aspergillus) screening twice weekly for the diagnosis of invasive aspergillosis. There were five proven and four probable invasive aspergillosis cases. The sensitivity, specificity and positive and negative predictive values were 100, 88, 47 and 100%, respectively. There were eight patients with false positive GM (10.2%). In six patients the false GM reactivity was due to the administration of piperacillin-tazobactam (P-T). A significant association was found between false positive GM (= or > 0.5) and the administration of P-T (p < 0.01). Two other patients with no invasive aspergillosis (2.5%) and false GM reactivity had graft versus host disease (GVHD) and one of them had also mucositis grade IV. The kinetic patterns of false positive GM due to P-T is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Artifacts*
  • Aspergillosis / blood
  • Aspergillosis / diagnosis*
  • Biomarkers
  • Combined Modality Therapy
  • Enzyme-Linked Immunosorbent Assay*
  • False Positive Reactions
  • Female
  • Fungemia / blood
  • Fungemia / diagnosis*
  • Galactose / analogs & derivatives
  • Graft vs Host Disease / blood
  • Graft vs Host Disease / complications
  • Hematologic Neoplasms / blood*
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / drug therapy
  • Hematologic Neoplasms / surgery
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Mannans / blood*
  • Middle Aged
  • Mucositis / blood
  • Mucositis / complications
  • Neutropenia / chemically induced
  • Neutropenia / complications
  • Penicillanic Acid / analogs & derivatives
  • Penicillanic Acid / pharmacology
  • Penicillanic Acid / therapeutic use
  • Piperacillin / pharmacology
  • Piperacillin / therapeutic use
  • Piperacillin, Tazobactam Drug Combination
  • Predictive Value of Tests
  • Prospective Studies
  • Sensitivity and Specificity

Substances

  • Anti-Bacterial Agents
  • Biomarkers
  • Mannans
  • galactomannan
  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • Piperacillin
  • Galactose