Power calculation for case-cohort studies with nonrare events

Biometrics. 2007 Dec;63(4):1288-95. doi: 10.1111/j.1541-0420.2007.00838.x. Epub 2007 Jun 30.

Abstract

Case-cohort design has been advocated in many epidemiologic studies when studying rare diseases or events. In this design, with a rare event, all the events are selected for risk-factor assessment. When the event is not rare, it is desirable to consider a generalized case-cohort design, where only a fraction of events are sampled. We provide a valid test statistic to compare hazards functions between two samples for this generalized design and give a method for calculating power. Our result generalizes the result in Cai and Zeng (2004, Biometrics60, 1015-1024), and it shows numerically that efficiency loss due to sampling only part of the events is very low under nonrare-events situation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Case-Control Studies*
  • Cohort Studies*
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Humans
  • Models, Biological*
  • Models, Statistical
  • Rare Diseases / epidemiology*