Host genetics: fine-tuning innate signaling

Curr Biol. 2007 Jul 3;17(13):R516-8. doi: 10.1016/j.cub.2007.04.052.

Abstract

A polymorphism modulating innate immunity signal transduction has recently been shown to influence human susceptibility to many different infections, providing one more indication of the potential of host genetics to reveal physiological pathways and mechanisms that influence resistance to infectious diseases.

MeSH terms

  • Genetic Predisposition to Disease*
  • Humans
  • Immunity, Innate / genetics*
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / immunology
  • Polymorphism, Single Nucleotide
  • Receptors, Interleukin-1 / genetics*
  • Receptors, Interleukin-1 / immunology
  • Selection, Genetic
  • Signal Transduction / immunology*

Substances

  • Membrane Glycoproteins
  • Receptors, Interleukin-1
  • TIRAP protein, human