Abstract
Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various antiarrhythmic agents, there remains a cohort of patients who fail to respond to conventional antiarrhythmic therapy therefore, amplifying the electrical storm. We report a case of a BS diagnosed via procainamide challenge, the resultant near fatal electrical storm aggravated by amiodarone and the eventual resolution with isoproterenol.
MeSH terms
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Adrenergic beta-Agonists / therapeutic use*
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Amiodarone / adverse effects*
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Anti-Arrhythmia Agents
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Brugada Syndrome / diagnosis
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Brugada Syndrome / physiopathology*
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Defibrillators, Implantable
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Electrocardiography
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Female
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Humans
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Isoproterenol / therapeutic use*
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Middle Aged
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Procainamide
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Tachycardia, Ventricular / chemically induced*
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Tachycardia, Ventricular / physiopathology
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Tachycardia, Ventricular / prevention & control
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Vasodilator Agents / adverse effects*
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Ventricular Fibrillation / chemically induced*
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Ventricular Fibrillation / physiopathology
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Ventricular Fibrillation / prevention & control
Substances
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Adrenergic beta-Agonists
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Anti-Arrhythmia Agents
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Vasodilator Agents
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Procainamide
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Isoproterenol
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Amiodarone