Abnormally expanded pro-B hematogones associated with congenital cytomegalovirus infection

Am J Hematol. 2007 Oct;82(10):934-6. doi: 10.1002/ajh.20986.

Abstract

Hematogones are nonleukemic immature lymphocytes that display a B-precursor phenotype and populate the pediatric bone marrow. We present the case of a newborn with an atypical, marked expansion of hematogones similar to the pro-B cells of infant acute lymphoblastic leukemia, which demonstrated their nonleukemic nature through gene rearrangement analysis and were associated with a congenital cytomegalovirus infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use
  • Bone Marrow / pathology
  • Cytomegalovirus Infections / congenital
  • Cytomegalovirus Infections / diagnosis*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / transmission
  • Diagnosis, Differential
  • Female
  • Ganciclovir / therapeutic use
  • Hepatitis, Viral, Human / congenital
  • Hepatitis, Viral, Human / surgery
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / blood
  • Infant, Premature, Diseases / diagnosis*
  • Infant, Premature, Diseases / drug therapy
  • Infant, Premature, Diseases / surgery
  • Infectious Disease Transmission, Vertical
  • Liver Transplantation
  • Lymphocyte Subsets / pathology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis

Substances

  • Antiviral Agents
  • Ganciclovir