Abstract
Piper longum L. has been used as a crude drug for the treatment of the disorder of peripherally poor blood circulation in Asia. In the present study, we examined the effect of piperlongumine, a constituent of P. longum L., on rabbit platelet aggregation. Piperlongumine concentration-dependently inhibited platelet aggregation induced by thromboxane A(2) receptor agonist U46619, but it only slightly inhibited thrombin-induced one. Piperlongumine also inhibited U46619-induced phosphatidylinositol hydrolysis and the binding of [(3)H]SQ29548 to thromboxane A(2) receptor with a similar concentration-dependency to the aggregation. It is assumed that piperlongumine inhibits platelet aggregation as a thromboxane A(2) receptor antagonist.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
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Animals
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Bridged Bicyclo Compounds, Heterocyclic
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Dioxolanes / pharmacology*
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Fatty Acids, Unsaturated
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Hydrazines / pharmacology
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Male
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Phosphatidylinositols / metabolism
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Piper / chemistry*
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / pharmacology*
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Rabbits
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Receptors, Thromboxane A2, Prostaglandin H2 / agonists
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Receptors, Thromboxane A2, Prostaglandin H2 / antagonists & inhibitors*
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Dioxolanes
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Fatty Acids, Unsaturated
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Heterocyclic Compounds, 1-Ring
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Hydrazines
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Phosphatidylinositols
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Platelet Aggregation Inhibitors
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Receptors, Thromboxane A2, Prostaglandin H2
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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SQ 29548
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piperlongumine