Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivo

Exerc Sport Sci Rev. 2007 Jul;35(3):97-101. doi: 10.1097/JES.0b013e3180a03169.

Abstract

Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor gamma coactivator 1alpha gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1alpha gene in skeletal muscle in vivo.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / genetics*
  • Mice
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism
  • Muscle, Skeletal / metabolism*
  • PPAR alpha / genetics*
  • PPAR alpha / metabolism
  • Physical Conditioning, Animal / physiology*
  • Transcription Factors / genetics
  • Transcription, Genetic*
  • p38 Mitogen-Activated Protein Kinases / genetics
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Mitochondrial Proteins
  • PPAR alpha
  • Transcription Factors
  • p38 Mitogen-Activated Protein Kinases