Abstract
The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Anthracyclines / pharmacology*
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Antibiotics, Antineoplastic / pharmacology*
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Cell Survival / drug effects
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Doxorubicin / pharmacology
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Enzyme Inhibitors
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Heart Diseases / chemically induced
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Heart Diseases / physiopathology
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Humans
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Oxidative Stress / drug effects
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Phospholipids / metabolism
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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Enzyme Inhibitors
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Phospholipids
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Doxorubicin
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Phospholipases A
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Phospholipases A2